Unlike other forms of lycanthropy, the effect of this spell can be broken by remove curse or break enchantment. By resisting the curse, a lycanthrope retains its normal alignment and personality while in humanoid form. The third level spell "remove curse" cures it by RAW, but you could make it more difficult to cure if you wanted as it is your world. A remove curse spell can rid an afflicted lycanthrope of the curse, but a natural born lycanthrope can be freed of the curse only with a wish. Have them do int checks or research the requirements for the cure. If a magic item places a curse on you, say that you can't heal properly, then the Remove Curse will get rid of it. At your touch, all curses affecting one creature or object end. Similarly, werebeasts cursed by a bite can be cured by the Remove Curse spell.
You can induce any type of common lycanthropy (and evil clerics frequently experiment with new kinds). This type of use, of course, is not affecting the item itself. A humanoid who fails the saving throw contracts lycanthropy, and the condition manifests with the next full moon. If the object is a cursed magic item, its curse remains, but the spell breaks its owner's attunement to the … Yeah, by the rules a simple remove curse spell cures lycanthropy. To make it a ritual with some chance of failure, you could call for a series of Wisdom checks, perhaps as a skill challenge, where the caster needs to get 3 successes before they get 3 failures or something. It is a curse. Lycanthrope Traits and Mechanics (5e) Usually assuming a challenge rating of 3 or 4, werebeasts become easy to defeat when magic weapons are involved. The pallies don't get third level spells until lvl 9, but wizards or clerics could do it at lvl 5. The Remove Curse will also break the connection between the item and the 'person' it is currently attuned (bonded) to, as in the item description, which doesn't affect the item all either, only the current owner.
A lycanthrope can either resist its curse or embrace it.