selenium deficiency keshan disease

Author information: (1)Institute of Nutrition and Food Safety, Chinese Centre for Disease Control and Prevention, Beijing, China. Selenium (Se) intake disequilibrium is associated with many human diseases (e.g., Keshan disease and type 2 diabetes). To understand the mechanism of … Selenium is an antioxidant in the enzyme selenium-glutathione peroxidase. Selenocystein kommt in dem Enzym Glutathionperoxidase vor, das im menschlichen Körper an der Abwehr oxidativen Stresses beteiligt ist. 262 It gives rise to an endemic cardiomyopathy that affects children between 1 and 9 years of age living in an area extending from the northeast to the southwest of China where the content of selenium in the soil and food is very low. Selenium Deficiency Diseases. Three specific diseases have been associated with selenium deficiency: Keshan Disease, which results in an enlarged heart and poor heart function in selenium-deficient children; Kashin-Beck Disease, which results in osteoarthritis in children; and Myxedematous Endemic Cretinism, which results in mental retardation in infants born to mothers deficient in both selenium and iodine. Keshan disease, an endemic cardiomyopathy occurring in low-selenium areas of China and Russia, is associated with low selenium intake and low blood and hair levels, and affects mainly children and women of childbearing age.The main clinical features of Keshan disease are cardiac … Keshan Disease, Selenium Deficiency, and the Selenoproteome List of authors. Keshan disease is an illness that is a direct result of a deficiency in the mineral selenium. Selenium is part of a nutritional antioxidant system that protects cell membranes and structural membranes from lipid peroxidation. Keshan disease (KD) is a dilated cardiomyopathy closely related with a diet deficient in the mineral selenium. Selenium Deficiency Diseases. Clinical Implications of Basic Research from The New England Journal of Medicine — Keshan Disease, Selenium Deficiency, and the Selenoproteome It focuses on deficiency of selenium in the environment and its effect on human health, particularly Keshan disease. Keshan disease is a congestive cardiomyopathy caused by a combination of dietary deficiency of selenium and the presence of a mutated strain of Coxsackievirus, named after Keshan County of Heilongjiang province, Northeast China, where symptoms were first noted. It is named for the northeastern Chinese county Keshan, where the disease prevalence is high because of selenium-deficient soil.

Keshan Disease Research Group of the Chinese Academy of Medical Sciences, 1979, Observation on the effect of sodium selenite in prevention of Keshan disease, Chinese Med. Keshan disease (KD) is a dilated cardiomyopathy closely related with a diet deficient in the mineral selenium. An original discovery: selenium deficiency and Keshan disease (an endemic heart disease). Die Keshan-Krankheit ist eine Erkrankung des Herzmuskels (Kardiomyopathie), die vor allem in selenarmen Gegenden auftritt. Deficiency of selenium, also known as Keshan disease, affects children living in areas with a poor content of selenium in the soil or those having a poor diet.


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